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Milkweed Poisoning of Horses

Guide B-709
Jason L. Turner, Keith Duncan, Kyle Tator
College of Agricultural, Consumer and Environmental Sciences, New Mexico State University

Authors: Respectively, Extension Horse Specialist, Department of Extension Animal Sciences and Natural Resources, Extension Brush and Weed Specialist, Department of Extension Animal Sciences and Natural Resources, and Valencia County Extension Agent, all of New Mexico State University. (Print Friendly PDF)


There are a wide variety of milkweed plants responsible for poisoning and death of horses. These plants grow in a range of soil and moisture conditions, from roadsides and ditches to pastures and rangelands. The growing season varies with the particular species, but growth (and the greatest incidence of poisoning) occurs primarily in warm weather from March to September.

Description of plant

Milkweed (Asclepias spp.) is an erect-stemmed, herbaceous perennial plant that grows from 3 to 4 feet tall (Figure 1). The more common species can be differentiated by their leaf shape and arrangement as well as the color of the flowers. The plants are characterized by the thick, milky sap that seeps out when the plant stem is broken. Milkweed seed pods contain many seeds, with each seed having a tuft of silky white hairs. For more information on identifying milkweed varieties, consult your local county Extension agent or NMSU Extension Circular 531, Livestock-Poisoning Plants of New Mexico Rangelands. (

Fig. 1: Horsetail milkweed (Asclepias subverticillata) is one of the more toxic species of milkweed plants.

Figure 1. Horsetail milkweed (Asclepias subverticillata) is one of the more toxic species of milkweed plants.

Toxic principles

The toxic nature of milkweed is due to one of two agents: cardiac glycosides (cardenolides) or an unidentified neurotoxin. The cardiac glycosides are found in the majority of milkweed species, while the neurotoxin is specific to the whorled-leaf types such as horsetail milkweed. Of the two, the neurotoxin is the most lethal.

The lethal dose of milkweed varies among species and, to a lesser extent, plant parts, but consuming green plant material in an amount equivalent to 0.005 to 2.0% of the horse's body weight is considered to be a toxic dose. For a 1,000-pound horse, this toxic dose could be between 1/2 and 20 pounds of plant matter. While the fresh, green plant material is the most toxic, dried plants present in pastures or hay retain their toxicity.


Signs of milkweed poisoning due to cardiac glycosides include depression and reluctance to stand, irregular heartbeat, colic, dilated pupils, muscular weakness or tremors and uncoordinated gait, and labored breathing, with death following within 24 hours. Unlike the neurotoxicity described below, poisoning due to cardiac glycosides rarely results in convulsions, so death usually occurs without signs of struggle.

Signs of whorled milkweed poisoning affecting the nervous system include severe colic, dilated pupils, muscle tremors and falling down, incoordination, violent convulsions, and respiratory failure, normally leading to death within 24 hours of ingesting the toxin.

If you believe that your horse may have been exposed to milkweed toxins, remove the suspect feed immediately and call your veterinarian. He or she may be able to administer a course of treatment that can help minimize the absorption of the toxic compounds by the digestive system. Supportive therapy may aid horses in combating the neurotoxicity symptoms.

Management: Prevention and Control Measures

Milkweed is very unpalatable, and horses do not readily consume it. The risk of poisoning increases when pastures or rangelands are overgrazed and horses have no other suitable forage to eat. Therefore, horse owners should closely monitor grazing conditions on their pasture or range to prevent overuse, and develop a weed management plan for areas such as field edges, fence lines, irrigation ditches, and roadsides where milkweed infestation is more common. In addition to sound grazing management, herbicides can be an important component of a comprehensive weed management plan. Herbicides that are currently labeled for control of milkweed are listed in Table 1.

The greatest incidence of milkweed poisoning in horses occurs when milkweed species have been baled along with the normal hay crop. Although horses may be able to sort broadleaf and course-stemmed milkweed plants from the hay, the whorled-leaf plants commonly found in hay fields have finer stems and leaves, making them more difficult to find and sort out. While horse owners should always be diligent in inspecting hay and grain as it is fed to their horses, they should be extra cautious when feeding hay that is harvested from high-risk areas (such as field edges or roadsides) where milkweed infestation is likely to occur.


Table 1. Herbicides and Application Rates for Control of Milkweed on Rangeland and Pastures
Common Name Trade Name Application Rate
Time of Application
Picloram Tordon 22k 1 qt Seedling to bloom
Picloram: 2, 4-D Grazon P + D 1 to 2 qt  
Dicamba Banvel, Clarity 1 pt  
Dicamba: 2, 4-D Weedmaster 1 to 2 qt  
Chlorsulfuron Telar XP 1/2 to 1 oz  
Metsulfuron Escort XP 5/8 to 4/5 oz  
Cimarron Plus 8/10 to 1 oz  
Metsulfuron + 2,
4-D: dicamba
Cimarron Max

Rate II
1/2 oz + 2 pt




Although milkweed is unpalatable to horses, the potential for death due to ingestion of the plant is high. Therefore, horse owners should take appropriate measures to rid their pastures of milkweed and ensure that the hay they provide their horses is safe and free of milkweed. As is the case with many plant poisonings, preventing consumption of the plant is the only guaranteed means of avoiding toxicity and potential death.


Allison, C.A. 2008. Livestock-Poisoning Plants of New Mexico Rangelands (Circular 531). Las Cruces: New Mexico State University Cooperative Extension Service.

Burrows, G.E. and R.J. Tyrl. 2001. Asclepiadaceae R.Br., in Toxic Plants of North America (p. 125–135). Ames, IA: Iowa State University Press.

Hart, C.R., T. Garland, A.C. Barr, B.B. Carpenter, and J.C. Reagor. 2003. Toxic Plants of Texas (p. 34–39). College Station: Texas Cooperative Extension Service.

Knight, A.P. 1995. Plant Poisoning of Horses, in L.D. Lewis, Equine Clinical Nutrition: Feeding and Care (p. 486–489). Philadelphia: Williams and Wilkins.

Knight, A.P. 2003. Asclepias, in A Guide to Poisonous House and Garden Plants. Available from International Veterinary Information Service, Accessed August 16, 2010.

Milkweed (Asclepias spp.). Retrieved August 16, 2010, from

Image of Jason L. Turner, Associate Professor and Extension Horse Specialist at New Mexico State University

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Printed and electronically distributed in December 2010, Las Cruces, NM.